How do I apply to become a patient?

To start your evaluation, please schedule a consultation.

How are the stem cells collected?

We receive cord donations after normal c-section births from healthy women. Our donors sign a consent form, fill out a detailed questionnaire, and give a blood sample. The mothers’ blood undergoes extensive testing for HIV, STD’s, hepatitis, etc.

How are the stem cells administered?

Stem cells are administered several ways depending on each patient’s ailment and physical condition. Patients typically receive a minimum of 3 stem cell applications during the course of an entire treatment protocol.  Methods of administration include: Intravenous (IV), intramuscular, intrathecal, and intra-articular.

Are there any long-term side effects?

Generally speaking, aside from the initial pain at the injection site, the patient will not experience any discomfort. Less than 10% of (mostly lumbar puncture) patients have developed a minor fever, headache, nausea or vomiting. However , these side effects have never lasted more than three days and usually resolve within 24 hours. No long-term negative side effects have been reported.

How long will it take to see results?

Each patient is unique, and there is no guarantee that positive results will be seen or how quickly they may be observed. Some patients have reported improvements during the course of their treatment, while others have experienced improvements as long as 6 months after returning home. 

What is the treatment protocol for my disease/disorder and how long does it take?

Treatment protocols vary by disease. Each patient’s physical condition and other medical factors can vary. Most protocols last for 3 – 5 days and consist of 3 – 4 sessions. Find out more about conditions we treat under the tab What We Treat.

Is physical therapy or rehabilitation available?

For certain treatment protocols, physical therapy will be recommended by our medical team and provided during the course of treatment.

Will I be prescribed any drugs?

Typically, the doctors do not prescribe any medication as a part of your treatment. However, they may advise a circulating stem cell enhancing supplement regime following treatment.

Will insurance cover the cost of treatment?

Insurance companies do not cover stem cell therapy.

How much does this treatment cost?

Cost depends on the recommended treatment protocol and will be given to you in writing upon approval. If you would like to get a ballpark idea about how much a particular treatment protocol might cost, please contact us.  One of our patient coordinators will be happy to assist you.

Does smoking or drinking affect the therapy?

Alcohol consumption and cigarette smoking can both be detrimental to new progenitor stem cells. It is advisable that you do not smoke or drink during your treatments.

Are there ethical issues involving these types of stem cell therapy?

Adult stem cells are not encompassed by the controversy surrounding fetal and embryonic stem cells. Both the Catholic Church and the Southern Baptist Church have issued papers which actually encourage research and the use of adult stem cells in the treatment of human disease as an ethically acceptable alternative to the use fetal and embryonic stem cells.

What are mesenchymal stem cells (MSCs)?

Stem cells are the body's raw materials — cells from which all other cells with specialized functions are created. Mesenchymal stem cells are adult stem cells that have self-renewal, immunomodulatory, anti-inflammatory, signaling, and differentiation properties.  Mesenchymal stem cells (MSCs), self renewal capacity is characterized by their ability to divide and develop into multiple specialized cell types present in a specific tissue or organ. Mesenchymal stem cells (MSCs) can be sourced from a variety of tissue including adipose tissue (fat), bone marrow, umbilical cord tissue, blood, liver, dental pulp, and skin.

Are the mesenchymal stem cells approved by the US FDA?

No stem cell product from any source is approved yet by the US FDA for any condition we treat. However, human umbilical cord tissue-derived mesenchymal stem cells (MSCs) that were isolated and grown in our laboratory in Panama to create master cell banks have recently been used in the United States under US FDA regulation. These cells served as the starting material for cellular products used in MSC clinical trials for two Duchenne’s muscular dystrophy patients under US FDA’s designation of Investigational New Drug (IND) for single patient compassionate use. (IND 16026 DMD Single Patient).

What makes mesenchymal stem cells (MSCs) useful in a clinical setting?

Mesenchymal stem cells (MSCs) are widely used in the treatment of various diseases due to their self-renewable, differentiation, anti-inflammatory, and immunomodulatory properties. In-vitro (performed in a laboratory setting) and in-vivo (taking place in a living organism) studies have supported the understanding mechanisms, safety, and efficacy of MSC therapy in clinical applications.

There is a plethora of research surrounding the mechanisms of mesenchymal stem cells (MSCs).  Many studies have outlined their diversified capabilities.  These characteristics enable MSCs to be used in a variety of clinical settings for multiple degenerative conditions.  

Research is starting to suggest that umbilical cord tissue-derived MSCs (UC-MSCs) may be more potent than other sources of mesenchymal stem cells thus potentially increasing their clinical efficacy.

Differentiation: refers to the normal process by which a stem cell undergoes maturation to become more distinct in form and function. For example, a single mesenchymal stem cell has the potential to develop into various types of cells.

Immunomodulatory: Mesenchymal stem cells (MSCs) can regulate the immune system by promoting an inflammatory response when the immune system is under-activated and reducing inflammation when the immune system is over activated. MSCs can play a key role in preventing the immune system from attacking itself similar to what one may see in many autoimmune disorders.

Anti-inflammatory: The reduction of harmful inflammation within the body. Inflammation is a response from the immune system that is aimed at protecting the body from harmful external stimuli as well as aid and repair the body.  However, when over activated, inflammation can have a detrimental effect on the body.

Are mesenchymal stem cells (MSCs) safe?

Multiple peer-reviewed studies have found Mesenchymal Stem Cell Therapy to be a safe procedure.  Additionally, over the course of our study, there have been no reports of any long-term negative side effects from treatment.

What are UCT-MSC’s?

UCT-MSC’s are pure Umbilical Cord Tissue derived Mesenchymal Stem Cells. They have strong anti-inflammatory properties and are multipotent. UCT-MSC’s are capable of differentiating into heart muscle cells, bone cells, cartilage cells, skeletal muscle cells, liver cells and more.

Why use umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs)?

Umbilical cord tissue-derived mesenchymal stem cells have the ability to differentiate into different cell types and have the greatest proliferation rate of other types of stem cells (adipose, bone marrow, cord tissue). UC-MSCs are known to secrete growth factors, cytokines, and chemokines, improving different cell repair mechanisms.  These functions all assist the anti-inflammatory and immunomodulatory properties of MSCs.

Non-invasive cell product

The harvesting procedure of UC-MSCs is non-invasive as it does not require extraction from the patient.  The MSCs are taken directly from an area of an ethically donated human umbilical cord. UC-MSCs also have a higher proliferative potential than BMSCs and ASCs meaning they expand in vitro more effectively allowing for greater efficiency when obtaining higher cell numbers.

Studies have found that UC-MSCs genes related to cell proliferation (EGF), PI3K-NFkB signaling pathway (TEK), and neurogenesis (RTN1, NPPB, and NRP2) were upregulated (increase in the number of receptors) in UC-MSCs compared to in BM-MSCs. 

Is there any chance my body rejects mesenchymal stem cells (MSCs)?

Mesenchymal stem cells derived from umbilical cord tissue are universally accepted and have no chance of rejection. Cord tissue derived MSCs are essentially “brand new” and immuno-privileged, unclaimed by the body.

Additionally, unlike other forms of treatment such as an organ transplant, there are no blood products used, and there is no HLA matching required. Umbilical cord tissue-derived mesenchymal stem cells (MSCs) face no chance of rejection when administered.

Can stem cells help with anti-aging?

With our current knowledge of stem cells, it is technically feasible to delay aging and improve both health and lifespan. Stem cells can play a crucial role in delaying the aging process. Stem cells, in combination with anti-aging genes, can create a sophisticated shield, which can prevent the effects of aging.

Stem cells, play a crucial role in delaying the aging process. Stem cells make a complex and protective shield, which stand against the eroding effects of aging. The shield of stem cells is a primary target for absorbing the shock of aging. If this shield neutralizes the shocks, it could lead to a youthful state. Studies suggest that stem cell interventions that increase rejuvenation and keep in balance the expression of anti-aging genes could delay aging and result in prolonged lifespan.

The benefits of a stem cell transplant for aging:

A feeling of vitality and rejuvenation

Improved capacity for physical activities

Thickening and improved quality of hair

Increased libido

A decrease in pain

Increased strength, balance & overall mobility

Enhanced immunity

Overall improvement in the quality of life

Immune system regulation

Decreased inflammatory markers

Can MSCs cause Graft vs. Host Disease?

MSCs can reduce the incidence of GVHD, but they cannot cause GVHD. ‍

Mesenchymal stem cells (MSCs) have been studied as a potential therapy for graft-versus-host disease (GVHD). MSCs have been shown to promote an immunosuppressive and immunoregulatory environment via multifactorial mechanisms, including secretion of proteins/peptides/hormones, transfer of mitochondria, and transfer of exosomes or microvesicles containing RNA and other molecules.

While most studies have revealed that MSC therapy benefits acute and chronic GVHD, there is still a lack of large-scale randomized clinical trials to verify these findings. It is important to note that while MSCs can inhibit the proliferation and secretion of T-lymphocytes and B-lymphocytes, they do not have or have very low immunosuppressive capacity.

What conditions can stem cells help?

Mesenchymal stem cell therapy may be able to help treat a variety of different conditions. The stated primary goal of our protocol is the marked reduction in the levels of chronic low-grade inflammation for an extended period of time. Stem cells have a unique, intrinsic property that attracts them to inflammation in the body. Studies have shown that stem cells can regenerate damaged or diseased tissues, reduce inflammation and modulate the immune system promoting better health and quality of life.

Studies have shown that mesenchymal stem cells (MSCS) may positively impact the following conditions:

ALS Alzheimer's Autoimmune conditions

COPD (or other degenerative / inflammatory lung conditions)

COVID-19 (long-haul / acute)

Chronic Inflammation

Crohn's Disease

Diabetes (Type 1)

Heart Failure / Heart Disease

Kidney Disease

Liver Disease

Lupus

Lyme Disease

Multiple Sclerosis

Neurological Conditions (degenerative)

Neuropathy

Parkinson's

Reflex Sympathetic Dystrophy (RSD) or (CRPS)

Rheumatoid Arthritis

Spinal Cord Injuries

Stroke (ischemic & hemiplegic)

Traumatic Brain Injury (TBI)

If you do not see your condition listed above or in the What We Treat section, please schedule a consultation so that our medical team may review your case and properly advise you.

Office: Delray, Florida

Call xxx-xxx-xxxx

Email: Heal@Bioregenwellness.com

Site: www.bioregenwellness.com

Copyright 2023 . All rights reserved